Poly(ADP-ribose) (PAR) is synthesized from NAD + by PAR polymerases (PARPs) and regulates many physiological processes such as the maintenance of DNA integrity, gene expression and cell division.
ADP-ribosylation is an ancient post-translational modification found in viruses, bacteria and eukaryotes 1. It is catalyzed by members of the ART superfamily of proteins, which transfer ADPr from ...
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