Cellular senescence plays a role in the development of aging-associated degenerative diseases. Cell therapy is recognized as a candidate treatment for degenerative diseases. To achieve the goal of ...

Cellular senescence is a stable cell fate marked by irreversible cell cycle arrest, apoptosis resistance and widespread remodeling of the secretory and metabolic landscape. A hallmark feature of this ...

Ovarian cancer is the most lethal malignancy of the female reproductive system. Due to its insidious early symptoms and the absence of specific screening modalities, approximately 70% of patients are ...

New research reveals that while losing weight can rejuvenate aging fat tissue, stubborn immune cells keep a “memory” of obesity, offering fresh targets for lasting metabolic health. Study: Selective ...

Figure 3. Mechanistic landscape of pro-longevity strategies. This figure illustrates the mechanistic action of key small-molecule drugs in clearing senescent cells, alongside immunotherapy strategies ...

In a recent study published in Nature Aging, researchers investigated whether sodium-glucose co-transporter 2 (SGLT2) inhibitors induce senolysis. Senescent cells, responsible for aging, amass in ...

Researchers at UC Berkeley have built a microfluidic organ-on-a-chip system that compresses roughly 40 years of human aging into just four days. The device, which pairs miniature models of fat and ...

A research team led by Professor Takuya Yamamoto (Department of Life Science Frontiers) and Professor Yasuhiro Yamada at the University of Tokyo has developed a novel in vivo system that reveals how ...

Cellular senescence is a state characterized by permanent cell-cycle arrest, increased expression of markers such as p16^INK4a and p21^CIP1/WAF1, elevated DNA damage signals (e.g., γ-H2AX) and a ...

"This is the first study to directly link senescence-related molecular networks in living human brain tissue to measurable differences in brain structure within the same individuals," said Noam ...

1 Sports Orthopedic Research Center–Copenhagen (SORC-C), Arthroscopic Center, Department of Orthopedic Surgery, Copenhagen University Hospital, Amager-Hvidovre, Hvidovre, Denmark Objective To ...