There have been recent insights from structural studies of Argonaute proteins, including human Argonautes. Mechanisms of small RNA loading and sorting into distinct Argonaute proteins are emerging.

RNA therapeutics have emerged as one of the most promising new classes of medicines. Eight small interfering RNA (siRNA) drugs have already been approved worldwide for the treatment of genetic ...

Neurons constantly adapt to new requirements. This plasticity is the molecular foundation of learning and remembering. At the cellular level, there is a variety of mechanisms for regulating general ...

Argonaute proteins inhibit gene expression by binding to messenger RNA via a small nucleic-acid guide. Structures of the Argonaute complex bound to target RNA reveal snapshots of a silencing machine ...

RNA therapeutics have emerged as one of the most promising new classes of medicines. Eight small interfering RNA (siRNA) drugs have already been approved worldwide for the treatment of genetic ...

Research by Victor Ambros, Ph.D., provides new insights into a recently identified class of neurodevelopmental disorders called Argonaute syndromes. Dr. Ambros and colleagues believe their Proceedings ...

Human Argonaute 1 protein (cyan) bound to let-7 microRNA (magenta). Ago protein family plays a role in RNA silencing processes. Cartoon model with semi-transparent surface. Shutterstock | petarg ...

The Argonaute (Ago) enzyme complex plays a critical role in DNA and RNA target cleavage for a process known as RNA silencing in prokaryotic and eukaryotic cells, making them a target for future ...

Scientists have unraveled the step-by-step activation process of a protein with a deep evolutionary history in all domains of life, opening the door to harnessing its functions for use as a ...

Greg Hannon's group at Cold Spring Harbor Laboratory was one of many labs scrambling to identify Slicer, the enzyme doing the cutting in RNA-mediated interference. Using biochemical mutagenesis, in ...