Upstream titers of 3–5 g/L, and up to 10–13 g/L, are outpacing downstream capacity, creating chromatography, filtration, and UF/DF throughput bottlenecks that elevate cost and delay timelines. Complex ...

Despite the importance of downstream bioprocessing, there are many opportunities for improvement, according to a report by Alois Jungbauer, PhD, a retired professor of biotechnology at the University ...

Downstream processing encompasses the suite of separation, purification and formulation steps required to convert fermentation broths or other bioreactor outputs into high-purity bio-based chemicals.

Models of biopharmaceutical production processes are more accurate and predictive if all downstream steps are considered together rather than individually. At least that’s according to researchers at ...

The two main fixation formats used by researchers are formalin fixation followed by paraffin embedding (FFPE) or snap-frozen in liquid nitrogen (referred to as Fresh Frozen or FF). There is less of a ...