Transmission electron microscopy reveals the architecture of cells at nanometer resolution, but chemical fixation severely warps their native structure. The true ultrastructure of cells can be ...

Scientists have developed a new imaging technique that uses a novel contrast mechanism in bioimaging to merge the strengths of two powerful microscopy methods, allowing researchers to see both the ...

Explore how correlative light and electron microscopy (CLEM) enables high-resolution insights into endocytic sorting.

The N.C. Brown Center for Ultrastructure Studies in Baker Laboratory provides instruction and assistance in light microscopy methods, scanning electron microscopy, transmission electron microscopy, ...

With a so-called cryo plasma-FIB (Plasma Focused Ion Beam) scanning electron microscope with nanomanipulator, Goethe University in Frankfurt (Germany) is expanding its research infrastructure with a ...

Electron microscope (EM) has revolutionised our ability to visualise the intricate details inside cells. The advancement to 3D electron microcopy, known as volume EM (vEM), has further expanded this ...

Researchers have combined two microscopic imaging techniques in one microscope, providing scientists with a high-resolution method of tracking single molecules in a cellular context. The development ...

Jeremy Berg does not work for, consult, own shares in or receive funding from any company or organization that would benefit from this article, and has disclosed no relevant affiliations beyond their ...

For more than 50 years, freeze-fracture electron microscopy has been widely accepted as a significant method in microscopic structural and biological research. Although components of the approach were ...