Researchers introduced a yeast enzyme, ScURA, into human cells, enabling nucleotide synthesis independent of mitochondrial ...

While most enzymatic activity is conducted through chemical binding interactions between molecules, in some cases, the mere presence of an enzyme can affect intracellular functions. While exploring ...

Nucleotide synthesis—the production of the basic components of DNA and RNA—is essential for cell growth and division. In most ...

Man prides himself upon his growing mastery over nature, but in the ultimate biochemical analysis nature remains the master of man. With their most sophisticated laboratory glassware and corrosive ...

NUDT5 enzyme acts as a molecular scaffold that maintains metabolic balance. Inside every cell, a finely tuned metabolic network determines when to build, recycle or stop producing essential molecules.

Researchers developed C28, an engineered polymerase that efficiently synthesizes RNA at near-natural speeds with high accuracy. Created through directed evolution, the enzyme also performs reverse ...

From vaccines and diagnostics to emerging gene-based therapies, RNA molecules are now central to modern medicine. But as their use continues to grow, so does a fundamental challenge: producing RNA ...

Amide bonds are common in drugs because they are chemically stable, form readily and are biocompatible. They also help ...

A single type of chemical structure that shows up again and again in modern medicine is the amide bond that links a carbonyl group (C=O) to a nitrogen atom. They're so ubiquitous that 117 of the top ...

Chemical structure of imatinib, a precision cancer drug containing an amide bond. Xiaoguang Lei and his team used their engineered enzyme to streamline the synthesis of imatinib, a landmark cancer ...

Macrolides are an important class of antibiotics that includes drugs such as azithromycin and erythromycin, which are widely used to treat a range of infections, including pneumonia and skin ...