About one-third of all drugs approved by the Food and Drug Administration target the largest family of cell membrane receptors called G protein-coupled receptors (GPCRs). GPCRs are indispensable for ...

For decades, dopamine signaling was viewed primarily through the lens of motor vigor—how fast or forcefully one moves. However, a landmark 2025 study from Karolinska Institutet published in Nature ...

New research led by the University of Minnesota Medical School demonstrates that molecules acting as "molecular bumpers" and "molecular glues" can rewire G protein-coupled receptor (GPCR) signaling, ...

Opioid receptors are fantastic targets for treating pain—but unfortunately, the drugs that target them can be addictive. Because the molecules suppress breathing and heart function, those drugs can ...

Understanding what causes a compound to be a biased modulator is a key step in enabling the design of compounds with more precision in the array of G proteins that they activate. The scientists ...

The 5th GPCRs-Targeted Drug Discovery Summit is a focused forum spotlighting the renaissance of GPCR-targeted therapeutics. This event guide explores novel screening platforms, structural biology ...

G protein-coupled receptors (GPCRs) are expressed on the surface of cells and regulate a range of important functions. Because they are involved in so many sensory and physiological processes, ...

A new Focus by Andreas Papassotiropoulos and Dominique de Quervain dissects a recent study published in the April 30 issue of Science Signaling, which showed that targeting the scaffolding protein ...