An innovative CRISPR-Cas12f-based activator system may hold significant potential in the future of gene therapy and biological research, suggest researchers of a new study. The study highlights the ...

Scientists at the MRC Laboratory of Medical Sciences (LMS) have discovered a DNA-based “dimmer switch” that regulates the activity of a critical developmental gene, Cdx2. This work could pave the way ...

To help achieve more precise control of gene therapy, engineers have designed a new control circuit that can keep gene expression levels within a target range. The method could be used to deliver ...

In a new study published in Genes & Development, research led by Dr. Lila Allou at the MRC Laboratory of Medical Sciences (LMS) in London and Professor Stefan Mundlos at the Max Planck Institute for ...

Every cell in our body contains the same DNA, yet liver cells are different from brain cells, and skin cells differ from muscle cells. What determines these differences? It all comes down to gene ...

It could be simply to control gene expression." The study, "Global impact of unproductive splicing on human gene expression levels and traits," was supported by funding from the National Institutes of ...

A new software package called CREsted, published in Nature Methods, gives researchers an end-to-end workflow for modeling and designing the DNA sequences that switch genes on and off in specific cell ...

Enhancers are pieces of DNA that act like switches, regulating when genes are turned on and off and how strongly they are activated.

urning genes on and off is like flipping a light switch, controlling whether genes in a cell are active. When a gene is turned on, the production of proteins or other substances is promoted; when it's ...