Thirty years after its discovery, scientists are eyeing leptin with renewed interest, for everything from weight loss drug ...

A growing body of research suggests the brain plays a central role in diabetic ketoacidosis, opening the possibility of treating type 1 diabetes in an entirely new way.

More than a decade ago, researchers found that an acute complication of type 1 diabetes, diabetic ketoacidosis (DKA), can be resolved with the hormone leptin, even in the absence of insulin. DKA ...

Anil Oza is a general assignment reporter at STAT focused on the NIH and health equity. You can reach him on Signal at aniloza.16. The hormone leptin was discovered 30 years ago to much fanfare.

For more than a hundred years, insulin has been the key to controlling type 1 diabetes. It has saved lives by preventing diabetic ketoacidosis (DKA), a life-threatening condition that happens when the ...

Hormone absence or inactivity is common in congenital disease, but hormone antagonism remains controversial. Here, we characterize two novel homozygous leptin variants that yielded antagonistic ...

Most obese patients grow resistant to satiety signals from the hormone leptin. A new study shows that leptin sensitivity can be restored in mice, leading to weight loss. Worldwide obesity rates have ...

A study more closely links obesity to dementia, finding that leptin, a hormone that helps maintain normal body weight, is associated with better signal-transmitting brain white matter in middle-aged ...