Using sequencing techniques, researchers associated 51 mutations in mitochondrial DNA with amyotrophic lateral sclerosis (ALS), an incurable degenerative neurological disorder that leads to muscle ...

University of Nevada, Reno researchers Jeanne and David Zeh of the Department of Biology have received a five-year, $650,000 grant from the National Science Foundation to investigate the effects of ...

Doubly uniparental inheritance (DUI) of mitochondrial DNA (mtDNA) represents a rare and intriguing deviation from the standard model of strictly maternal inheritance. In bivalves, DUI manifests as the ...

A new study from deCODE genetics uses pedigrees and sequence data from 64,806 Icelanders to shed light on the rate and nature of mutations in mitochondrial DNA (mtDNA) and the peculiar dynamics of its ...

Geneticists looking inside the nuclear genome for mutations that contribute to disease have long relied on a principal known as constraint modeling, which allows researchers to assess the degree of ...

In most eukaryotes, the inheritance of mitochondrion and its DNA (mtDNA) is strictly maternal, despite the fact that a spermatozoon can inject up to 100 functional mitochondria into the oocyte during ...

Back in the 19 th century, as the US grappled with the aftermath of the Civil War, Jesse James, leader of a notorious gang of outlaws, rose to prominence. He robbed banks and trains for over a decade ...

The tiny little powerhouses of our cells: mitochondria, are unique among organelles because they carry their own tiny little genomes. This genetic material is separate from the rest of our genomic DNA ...

In a step toward treating mitochondrial diseases, researchers at the University Medical Center Utrecht and their colleagues have used mitochondrial base editing (mtBE) to successfully edit harmful ...