New research in Cell Division shows that Bcl-2 overexpression promotes survival of cutaneous squamous cell carcinoma cells by ...

A new study reports that MDM4 promotes glycolysis and proliferation in TP53-mutant oral squamous cell carcinoma by ...

Background The p53 protein is a central tumour suppressor regulating numerous genes involved in cell cycle control, DNA repair, and apoptosis. Mutations in p53 occur in over half of all cancers, ...

A team of researchers at VCU Massey Comprehensive Cancer Center has identified a new pathway through which mutations in the tumor suppressor p53 gene—found very frequently in human tumors—hijack DNA ...

Scientists discover how the Fas-p53 pathway sabotages energy metabolism, offering new hope for tackling obesity and improving insulin sensitivity. Brief Communication: Expression of p53 in human ...

Cancer arises when your cells grow uncontrollably and refuse to die when they should. Normally, your body is equipped with regulatory processes to prevent this chaos. One such mechanism involves a ...

Researchers at Uppsala University have adapted Cell Painting, a widely used imaging method in drug discovery, to look at ...

A tumor suppressor gene known as p53 is mutated in more than half of all cancers, but how it acts to prevent cancer formation is largely unknown. A study by UT Southwestern Medical Center researchers ...

Investigation of the association of CTRB2 exon 6 deletion with time to progression and overall survival in pancreatic ductal adenocarcinoma. This is an ASCO Meeting Abstract from the 2025 ASCO ...

Chemotherapy kills cancer cells, but researchers headed by a team at the Netherlands Cancer Institute have now found that the way these cells die appears to be different than previously understood.

A team of researchers at VCU Massey Comprehensive Cancer Center has identified a new pathway through which mutations in the tumor suppressor p53 gene—found very frequently in human tumors—hijack DNA ...