Thrombolytic treatment of ischemic stroke with tissue plasminogen activator (tPA) is markedly limited owing to concerns about hemorrhagic complications and the requirement that tPA be administered ...
IGF-1R inhibition effect on a yes/SFK bypass resistance pathway: Rational basis for cotargeting IGF-1R and yes/SFK kinase in rhabdomyosarcoma. Preclinical evidence of craniofacial adverse effect of ...
Systemic sclerosis (scleroderma) is characterized by immunologic abnormalities, injury of endothelial cells, and tissue fibrosis. Abnormal oxidative stress has been documented in scleroderma and ...
The vascular endothelium is under permanent hemodynamic frictional stress. Maintaining the integrity of the vasculature is essential for preventing aneurysmal dilatation and cholesterol infiltration, ...
PDGF-β-inhibiting activity of imatinib also reverses established tolerance. Platelet-derived growth factor receptor-β (PDGFR-β) inhibitors such as the anticancer drug imatinib (Gleevec) can prevent or ...
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