The APS, SH2-B and LNK proteins are adapters that activate and modulate receptor tyrosine kinase and JAK/STAT signaling. We now show that a conserved N-terminal domain mediates APS homodimerization.

Drexel University researchers and an international group of scientists have made a critical step toward understanding a disorder that affects patients from birth into adulthood. Phenylketonuria, or ...

Phenylalanine is an essential amino acid that carries out many important functions in the human body. The two types of phenylalanine are L-form and D-form. This article describes what phenylalanine is ...

PHENYLKETONURIA is a hereditary metabolic disease caused by a deficiency of the enzyme, phenylalanine hydroxylase. Data have been presented showing that the mental retardation in this condition can be ...

WEST LAFAYETTE, Ind. - Purdue University researchers have discovered a microbial-like pathway in plants that produces phenylalanine, an amino acid that is a vital component of proteins in all living ...

The folded structure consists of a sequence of loop and stem regions. The phosphate-sugar backbone is shown as a blue ribbon to which the nucleobases, shown as molecular structures, are attached. The ...

WEST LAFAYETTE, Ind. — Purdue University scientists Natalia Dudareva and Joseph Lynch have been searching for a way to increase a plant’s production of phenylalanine, a compound important for plant ...

Phenylalanine is an amino acid in plant and animal foods, such as meat, eggs, fish, and soy products. It is safe for most people, except for those with phenylketonuria, who may not be able to break it ...

The amino acid phenylalanine assembles into toxic fibrils, researchers at Tel Aviv University and the University of Zurich report (Nat. Chem. Biol., DOI: 10.1039/nchembio.1002). This is the first time ...