Antibodies targeting the normal PrP version of the prion protein have been found in humans selected at random with no history of any associated transmissible spongiform encephalopathies. The ...

The purpose of the prion protein (PrP), other than to beset cows, humans, and other animals with brain-wasting diseases, has been devilishly hard to figure out. In spite of the protein’s widespread ...

The alternative text for this image may have been generated using AI. If neuroinvasion can proceed in the absence of PrP C-bearing lymphocytes, what are its cellular and molecular requirements? Our ...

"Scrapie" is the old Scottish shepherds' name for a disease of their sheep which has been known for several centuries. It is the original example of a group of diseases, known as the "transmissible ...

In patients with sporadic Creutzfeldt–Jakob disease, pathologic disease-associated prion protein (PrP Sc) has been identified only in the central nervous system and olfactory-nerve tissue.

Normal cellular prion protein (PrPc) is easy to spot on the surface of neurons and glia in the CNS by antibody staining. But when the protein converts to its toxic scrapie-causing conformation (PrPSc) ...

Special proteins known as prions, which are perhaps best known as the agents of mad cow and other neurodegenerative diseases, can also serve as an important source of beneficial variation in nature.

No one expects to live a before-and-after kind of life, divided into the moments before and the moments after a single defining event. When the two of us met, fell in love and got married in Sonia’s ...

Transmissible forms of neurodegenerative diseases that are always fatal sounds terrifying, and almost like science fiction. Unfortunately, prion disorders like Creutzfeldt-Jakob disease (CJD) are very ...

Between COVID, HIV, Dengue, Ebola, and emerging flu variants, the last thing the world needs is another type of pathogen, let alone with no treatment or cure. But, although rare, prion diseases, such ...

The likely cause of cell death in brains infected with prion diseases has been revealed for the first time, say US researchers. The diseases, which include mad cow disease and its human form vCJD, are ...