Cell fate commitment is achieved by the establishment of cell type-specific transcriptional programs, which in turn are guided, reinforced, and ultimately locked-in by epigenetic mechanisms. In a new ...

The early stages of embryonic development contain many of life's mysteries. Unlocking these mysteries can help us better understand early development and birth defects, and help develop new ...

A new study published in Nature Biotechnology shows that stem cell differentiation is linked to cellular structures called P-bodies, providing a potential means of controlling cell identity.

They expand and interpret the information content of the genome. This occurs through co-transcriptional regulation of RNA biogenesis, in which RBPs mediate RNA processing such as splicing, cleavage ...

Chemical modifications on RNA molecules have emerged as a fundamental regulatory layer of gene expression, analogous to epigenetic marks on DNA and histones 1. Over the past 15 years, extensive ...

Researchers have produced the most detailed map yet of how stem cells in the growing tip of a plant begin their journey to form the many cell types ...