IN 1960 Lejeune et al. 1 noted a centric fusion of 2 13–15 chromosomes in the cells of a person with Klinefelter's syndrome, and in 1962 Walker and Harris 2,3 reported several generations of a family ...

Chromosomal translocations are frequently found to be associated with various malignant disorders as well as congenital abnormalities. We report the characterization of a novel reciprocal ...

MONGOLISM is usually the result of trisomy of a small acrocentric chromosome in Group 21–22 in the Denver Classification. This is generally referred to as 21-trisomy. These patients have a somatic ...

When chromosomes break, trouble usually ensues; chromosome abnormalities are the single biggest cause of birth defects in humans. But a new study of translocations, in which two chromosomes swap ...

Translocation is a genetic abnormality in which part of a chromosome moves to another chromosome. Chromosomes are genetic structures within cells that hold genes. When translocation occurs, it causes ...

When couples have trouble conceiving a baby or lose a pregnancy, they often undergo routine tests, which can turn up a shock: One of the prospective parents may be missing a chromosome. The most ...

July 1, 2009, New York, NY – Janet Davison Rowley, MD, a founder in the field of cancer cytogenetics and a renowned leader in molecular oncology, will receive the 2009 Genetics Prize of The Peter and ...