Researchers at the Cancer Research Institute and the Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, have uncovered a critical mechanism that enables gastric cancer to spread to ...

The Wnt family of secreted glycoproteins orchestrates an array of cellular processes by engaging membrane receptors and co-receptors to activate intracellular cascades. In the canonical pathway, Wnt ...

Targeting the WNT signaling pathway represents a promising strategy for cancer therapy. The field has evolved to include numerous inhibitors currently under preclinical and clinical investigation.

Wnt signalling is a highly conserved cellular communication cascade that regulates bone formation, remodelling and repair through the modulation of osteoblast and osteoclast activity. Activation of ...

Researchers have described a large set of previously unrecognized enzymatic domains—named the Lipocone superfamily—and outlined their evolutionary pathway from bacterial defense molecules to key ...

(A) The heatmap showing the differential expression of the Wnt proteins and the Wnt target genes between the GTEx cortex (n = 199) and TCGA-GBM (n = 173) datasets. (B) The spatial transcriptomic data ...