In the first step of spliceosome assembly, an snRNA molecule known as U1 snRNA binds to the 5' splice site at the beginning of the intron. Until now, it had been thought that the binding strength ...

Precursor messenger RNA is edited into its final form by an RNA–protein assembly called the spliceosome. Structural evidence provides insights into how the spliceosome is disassembled when its job is ...

In the first step of spliceosome assembly, an snRNA molecule known as U1 snRNA binds to the 5' splice site at the beginning of the intron. Until now, it had been thought that the binding strength ...

Small nuclear RNAs (snRNAs) are the basal components of the spliceosome and play crucial roles in splicing. Their biogenesis is spatiotemporally regulated. However, related mechanisms are still poorly ...

CAMBRIDGE, MA -- RNA splicing is a cellular process that is critical for gene expression. After genes are copied from DNA into messenger RNA, portions of the RNA that don’t code for proteins, called ...