Schematic model of how the new drug, D4, inhibits hemichannels and alleviates neuroinflammation and seizure symptoms. The new drug, D4, is a selective blocker of connexin hemichannels. Excessive ...
Engagement of intracellular targets is often critical to drug mechanisms. Establishing a target engagement (TE) profile is an important step in small- molecule drug discovery as well as chemical probe ...
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