Scientists organize millions of proteins by shape, as predicted by AI, revealing 700,000 new families and some shapes unique ...

A research team has unveiled a breakthrough in understanding how specific genetic sequences, known as pseudogenes, evolve. Rice University's Peter Wolynes and his research team have unveiled a ...

Synthesizing new proteins – the building blocks of biological life – is a scientific field of immense potential, and a newly developed AI model promises to create instructions for new proteins way ...

Scientists have developed a novel approach to modifying enzymes to improve functionality. They designed a new algorithm to make multiple changes to an enzyme sequence at once as compared to the ...

A new platform combines rational protein design with continuous evolution to discover functional molecules more efficiently. In medicine and biotechnology, the ability to evolve proteins with new or ...

Up-to-date computational pipeline characterizes G-protein-coupled receptor (GPCR) repertoires in the closest relatives of metazoans, providing a framework to investigate the evolutionary origins and ...

Protein evolution plays a key role in many biological processes that are essential for life – but what does it have to do with physics? Schematic overview of procedure used to generate simulated ...

In a remarkable leap forward for synthetic biology, the AI model ESM3, developed by Evolutionary Scale, has achieved a significant milestone. By simulating half a billion years of evolutionary ...

Protein design is crucial for the treatment of human diseases, but traditional protein design methods have some limitations. Site-directed mutagenesis is highly dependent on the physiological ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 115, No. 11 (March 13, 2018), pp. 2794-2799 (6 pages) In the white-throated sparrow (Zonotrichia albicollis), the ...