The heightened intrinsic activity resulting from loop confinement in enzymes arises synergistically from enthalpic and entropic contributions, which are contingent upon the extent of surface ...

Researchers at the Leibniz Institute on Aging - Fritz Lipmann Institute (FLI) in Jena found that oxidative stress in the ...

The team published its results in the April 20, 2022, issue of Science Translational Medicine. Stroke, which occurs when brain cells die following a disruption in the blood supply to the brain, is ...

Methylation is a key post-translational modification (PTM) of mammalian proteins and nucleic acids where unique enzymes known as methyltransferases (MTases) transfer methyl groups to a variety of ...

Just because an enzyme has an active site doesn’t mean the rest of the enzyme should be disregarded, as though it were so much dead weight. It influences enzyme function, if only by keeping the enzyme ...

A new study finds enhanced activity of a specific enzyme drives spinocerebellar ataxia type 14, which suggests inhibiting the enzyme may have therapeutic potential. pinocerebellar ataxias are a group ...