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vanderbilt.edu
Extracellular chloride signals collagen IV network assembly during basement membrane formation.
Basement membranes are defining features of the cellular microenvironment; however, little is known regarding their assembly outside cells. We report that extracellular Cl(-) ions signal the assembly of collagen IV networks outside cells by triggering a conformational switch within collagen IV noncollagenous 1 (NC1) domains. Depletion of Cl ...
Aug 3, 2018
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